Hearts of Oak will travel from Cape Coast to the Tema Stadium to face Inter Allies.
The Phobians have not recorded a win in their last two games and will need to put in their best to defeat Inter Allies.
Coach Henry Wellington will be hoping his charges will put in their maximum best to clinch all three points.
Inter Allies have been good at home this season and are currently been coach by former Hearts trainer Kenichi Yatsuhashi.
Liberty Professionals will welcome Kumasi Asante Kotoko at the Carl Reindorf Park.
The last Asante Kotoko visit to Dansoman ended in a loss as two goals former Liberty Captain Samuel Sarfo and Samuel Annan gave them all three points.
Both teams will go into the game with confidence as they recorded victories in their last respective matches.
League leaders Medeama SC will host Wa All Stars at the T&A Park.
Medeama who signed three players on deadline day hope to cement top spot in the league and will push to secure a win in this encounter.